Deficiency of the Metabolic Enzyme SCHAD in Pancreatic β-Cells Promotes Amino Acid-Sensitive Hypoglycemia

To test the hypothesis that enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD)-congenital hyperinsulinism of infancy arises from a specific defect in pancreatic β-cells, investigators created genetically engineered β-cell-specific or hepatocyte-specific SCHAD knockout mice.