NewslettersImmune Regulation News Dysregulated IFN-γ Signals Promote Autoimmunity in STAT1 Gain-of-Function Syndrome By Laurisa Dohm - July 7, 2023 0 To dissect underlying immune mechanisms, researchers generated Stat1 gain-of-function transgenic mice and confirmed the development of spontaneous humoral autoimmunity that recapitulated the human phenotype. [Science Translational Medicine] Abstract