NewslettersImmune Regulation News Both Intratumoral Regulatory T Cell Depletion and CTLA-4 Antagonism Are Required for Maximum Efficacy of Anti-CTLA-4 Antibodies By Laurisa Dohm - July 28, 2023 0 Scientists reported the engineering of a nonantagonistic CTLA-4 binding domain that depleted intratumoral Tregs as an Fc fusion. [Proceedings Of The National Academy Of Sciences Of The United States Of America] Abstract