Biomimetic Microenvironmental Stiffness Boosts Stemness of Pancreatic Ductal Adenocarcinoma via Augmented Autophagy

To understand the effect of the underlying interaction of matrix stiffness and stemness on pancreatic ductal adenocarcinoma, a methacrylated gelatin hydrogel with tunable stiffness was applied for incubating MIA PaCa-2 and PANC-1 cells.