Overexpression of ZNF488 Supports Pancreatic Cancer Cell Proliferation and Tumorigenesis through Inhibition of Ferroptosis via Regulating SCD1-Mediated Unsaturated Fatty Acid Metabolism

Human ESCcs were genetically modified to stably overexpress ferritin using the CRISPR-Cas9 system. Cellular toxicity associated with ferritin overexpression and manganese supplementation were assessed based on cell viability, proliferation, and metabolic activity.