NewslettersMuscle Cell News Plakophilin 2 Gene Therapy Prevents and Rescues Arrhythmogenic Right Ventricular Cardiomyopathy in a Mouse Model Harboring Patient Genetics By Noshin Noorjahan - December 7, 2023 0 Investigators generated a mouse model harboring a plakophilin 2 mutation affecting RNA splicing, recapitulating arrhythmogenic right ventricular cardiomyopathy features and sudden death starting at four weeks. [Nature Cardiovascular Research] Full Article