NewslettersESC & iPSC News Loss of Cohesin Regulator PDS5A Reveals Repressive Role of Polycomb Loops By lbeveridge - December 12, 2023 0 Using a CRISPR screen in mouse embryonic stem cells, investigators found that the cohesin regulator PDS5A links transcriptional silencing by Polycomb and 3D genome organization. [Nature Communications] Full Article