NewslettersDermal Cell News Differential Histone Acetylation and Super-Enhancer Regulation Underlie Melanoma Cell Dedifferentiation By Laurisa Dohm - February 12, 2024 0 Scientists identified ITGA3 gene as marked by a super-enhancer element in the Epgn3 invasive cells. Silencing of ITGA3 enhanced invasiveness in both in vitro and in vivo systems suggesting it as a negative regulator of invasion. [JCI Insight] Abstract