Researchers showed that circulating tumor cells isolated from immunotherapy-resistant metastatic melanoma patients expressed higher levels of nuclear lysine specific demethylase 1 (LSD1) phosphorylated at serine 111 compared to responders, which is associated with co-expression of stem-like, mesenchymal genes.
[Frontiers in Immunology]
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Tu, W. J., McCuaig, R. D., Tan, A. H. Y., Hardy, K., Seddiki, N., Ali, S., … Rao, S. (2020). Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01228 Cite
