Investigators observed that circadian disruption significantly increased cancer-cell dissemination and lung metastasis. It also enhanced the stemness and tumor-initiating potential of tumor cells and created an immunosuppressive shift in the tumor microenvironment.
[Nature Communications]
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Hadadi, E., Taylor, W., Li, X.-M., Aslan, Y., Villote, M., Rivière, J., Duvallet, G., Auriau, C., Dulong, S., Raymond-Letron, I., Provot, S., Bennaceur-Griscelli, A., & Acloque, H. (2020). Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice. Nature Communications, 11(1), 3193. https://doi.org/10.1038/s41467-020-16890-6 Cite
