The authors found that IL-17RB expression was significantly upregulated in spheroid cells and Lgr5-positive cells from the same tumor tissues of patients with gastric cancer, which was closely correlated with the degree of cancer cell differentiation.
[Oncogene]
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Bie, Q., Song, H., Chen, X., Yang, X., Shi, S., Zhang, L., Zhao, R., Wei, L., Zhang, B., Xiong, H., & Zhang, B. (2021). IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination. Oncogene, 1–17. https://doi.org/10.1038/s41388-021-01699-4 Cite
