Researchers showed significant metabolic alterations occur in gliomas when perturbing the expression of asparagine synthetase, which is not merely restricted to amino acid homeostasis.
[Molecular Cancer Research]
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Thomas, T. M., Miyaguchi, K., Edwards, L. A., Wang, H., Wollebo, H., Aiguo, L., Murali, R., Wang, Y., Braas, D., Michael, J. S., Andres, A., Zhang, M., Khalili, K., Gottlieb, R. A., Perez, J. M., & Yu, J. S. (2021). Elevated Asparagine Biosynthesis Drives Brain Tumor Stem Cell Metabolic Plasticity and Resistance to Oxidative Stress. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0086 Cite
