Researchers established a model of stepwise leukemogenesis in congenital neutropenia (CN)/acute myeloid leukemiausing CRISPR-Cas9 gene editing of CN patient-derived iPSCs.
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Dannenmann, B., Klimiankou, M., Oswald, B., Solovyeva, A., Mardan, J., Nasri, M., Ritter, M., Zahabi, A., Arreba-Tutusaus, P., Mir, P., Stein, F., Kandabarau, S., Lachmann, N., Moritz, T., Morishima, T., Konantz, M., Lengerke, C., Ripperger, T., Steinemann, D., … Skokowa, J. (2021). iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.03.023 Cite
