Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast cancer stem cells, which were potentially regulated by Wnt, TGF‐β, and Hedgehog signaling.
[Cancer Medicine]
6807162
WCHU7GBW
items
1
apa
0
default
asc
1
161895
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-557cb74174b9f37f61a8b5865213a015%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22WCHU7GBW%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shi%20and%20Yang%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EShi%2C%20H.%2C%20%26amp%3B%20Yang%2C%20Y.%20%28n.d.%29.%20Identification%20of%20inhibitory%20immune%20checkpoints%20and%20relevant%20regulatory%20pathways%20in%20breast%20cancer%20stem%20cells.%20%3Ci%3ECancer%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcam4.3902%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcam4.3902%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3DWCHU7GBW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Identification%20of%20inhibitory%20immune%20checkpoints%20and%20relevant%20regulatory%20pathways%20in%20breast%20cancer%20stem%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haojun%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yisi%22%2C%22lastName%22%3A%22Yang%22%7D%5D%2C%22abstractNote%22%3A%22Immune%20checkpoint%20blockade%20%28ICB%29%20has%20become%20one%20of%20the%20most%20promising%20approaches%20to%20activating%20antitumor%20immunity.%20However%2C%20only%20a%20small%20subset%20of%20patients%20with%20breast%20cancer%20benefit%20from%20ICB%20treatment.%20To%20improve%20the%20therapeutic%20effect%20in%20the%20clinic%2C%20precision%20immunotherapy%20is%20proposed%20to%20accurately%20eliminate%20cancer%20stem%20cells%20that%20contribute%20to%20local%20recurrence%20or%20metastasis%2C%20but%20currently%20little%20is%20known%20about%20their%20immunological%20properties.%20In%20this%20study%2C%20breast%20cancer%5Cu2013specific%20datasets%20in%20The%20Cancer%20Genome%20Atlas%20were%20collected%20and%20analyzed%20by%20using%20multiple%20open-access%20web%20servers.%20We%20found%20that%20the%20immunophenotype%20of%20breast%20cancer%20was%20characterized%20by%20a%20hypoactive%20immune%20microenvironment%20and%20a%20low%20response%20to%20immune%20checkpoint%20blockade.%20The%20innate%20immune%20checkpoint%20CD200%20and%20the%20adaptive%20immune%20checkpoint%20CD276%2C%20respectively%2C%20exhibited%20a%20strong%20correlation%20with%20basal%5C%2Fstem%20gene%20signature%20and%20invasiveness%20gene%20signature%2C%20both%20of%20which%20represent%20breast%20cancer%20stem%20cells.%20Wnt%2C%20TGF-%5Cu03b2%2C%20and%20Hedgehog%20signaling%2C%20which%20are%20recognized%20as%20stemness-related%20pathways%2C%20showed%20a%20significant%20association%20with%20the%20expression%20of%20CD200%20and%20CD276%2C%20suggesting%20cancer%20stem%20cell%5Cu2013specific%20immune%20checkpoints%20could%20be%20downregulated%20by%20inhibiting%20these%20pathways.%20Of%20note%2C%20levels%20of%20CD200%20and%20CD276%20expression%20were%20higher%20in%20TGF-%5Cu03b2%20dominant%20breast%20cancer%20than%20in%20other%20immune%20types%20of%20breast%20cancer.%20We%20also%20identified%20gene%20signatures%20that%20represent%20Wnt%2C%20TGF-%5Cu03b2%2C%20and%20Hedgehog%20signaling-related%20CD200%20and%20CD276%20expression%20in%20breast%20cancer%20stem%20cells.%20For%20the%20luminal%20A%20subtype%2C%20the%20patient%20group%20with%20a%20high%20level%20of%20these%20gene%20signatures%20plus%20a%20low%20infiltration%20of%20CD8%2B%20T%20cells%2C%20or%20dendritic%20cells%2C%20or%20M1%20macrophages%20had%20poor%20overall%20survival.%20Our%20study%20suggested%20that%20CD200%20and%20CD276%20are%20candidate%20inhibitory%20immune%20checkpoints%20in%20breast%20cancer%20stem%20cells%2C%20which%20are%20potentially%20regulated%20by%20Wnt%2C%20TGF-%5Cu03b2%2C%20and%20Hedgehog%20signaling.%20Synergistic%20inhibition%20of%20these%20stemness-related%20pathways%20may%20improve%20the%20efficacy%20of%20ICB%20treatment%20targeting%20breast%20cancer%20stem%20cells%20in%20precision%20immunotherapy.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcam4.3902%22%2C%22ISSN%22%3A%222045-7634%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fcam4.3902%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-04T20%3A48%3A47Z%22%7D%7D%5D%7D
Shi, H., & Yang, Y. (n.d.). Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3902 Cite
