Using multiplexed gene regulation with orthogonal CRISPR systems, researchers demonstrated improved neuronal differentiation with concurrent activation and repression of target genes, underscoring the power of CRISPR-based gene regulation for programming complex cellular phenotypes.
[Cell Reports]
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Black, J. B., McCutcheon, S. R., Dube, S., Barrera, A., Klann, T. S., Rice, G. A., Adkar, S. S., Soderling, S. H., Reddy, T. E., & Gersbach, C. A. (2020). Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens. Cell Reports, 33(9). https://doi.org/10.1016/j.celrep.2020.108460 Cite
