Researchers investigated the effects of reducing the dose of posttransplantation cyclophosphamide (PTCy) followed by α-galactosylceramide, a ligand of iNKT cells, on the reciprocal balance between graft-versus-host disease (GVHD) and the graft-versus-leukemia (GVL) effect.
[Scientific Reports]
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Nakamura, M., Meguri, Y., Ikegawa, S., Kondo, T., Sumii, Y., Fukumi, T., Iwamoto, M., Sando, Y., Sugiura, H., Asada, N., Ennishi, D., Tomida, S., Fukuda-Kawaguchi, E., Ishii, Y., Maeda, Y., & Matsuoka, K. (2021). Reduced dose of PTCy followed by adjuvant α-galactosylceramide enhances GVL effect without sacrificing GVHD suppression. Scientific Reports, 11(1), 13125. https://doi.org/10.1038/s41598-021-92526-z Cite
