Scientists found that high group 2 innate lymphoid cells (ILC2) infiltration in human melanoma was associated with a good clinical prognosis. ILC2s were critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinated the recruitment and activation of eosinophils to enhance antitumor responses.
[Nature Immunology]
7753456
{7753456:K9VGVIHC}
apa
50
1
163113
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-1fe977c247493a9e196bf24bae1ccd80%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22K9VGVIHC%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jacquelot%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EJacquelot%2C%20N.%2C%20Seillet%2C%20C.%2C%20Wang%2C%20M.%2C%20Pizzolla%2C%20A.%2C%20Liao%2C%20Y.%2C%20Hediyeh-zadeh%2C%20S.%2C%20Grisaru-Tal%2C%20S.%2C%20Louis%2C%20C.%2C%20Huang%2C%20Q.%2C%20Schreuder%2C%20J.%2C%20Souza-Fonseca-Guimaraes%2C%20F.%2C%20de%20Graaf%2C%20C.%20A.%2C%20Thia%2C%20K.%2C%20Macdonald%2C%20S.%2C%20Camilleri%2C%20M.%2C%20Luong%2C%20K.%2C%20Zhang%2C%20S.%2C%20Chopin%2C%20M.%2C%20Molden-Hauer%2C%20T.%2C%20%26%23x2026%3B%20Belz%2C%20G.%20T.%20%282021%29.%20Blockade%20of%20the%20co-inhibitory%20molecule%20PD-1%20unleashes%20ILC2-dependent%20antitumor%20immunity%20in%20melanoma.%20%3Ci%3ENature%20Immunology%3C%5C%2Fi%3E%2C%201%26%23x2013%3B14.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41590-021-00943-z%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41590-021-00943-z%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DK9VGVIHC%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Blockade%20of%20the%20co-inhibitory%20molecule%20PD-1%20unleashes%20ILC2-dependent%20antitumor%20immunity%20in%20melanoma%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Jacquelot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cyril%22%2C%22lastName%22%3A%22Seillet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minyu%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%22%2C%22lastName%22%3A%22Pizzolla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yang%22%2C%22lastName%22%3A%22Liao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soroor%22%2C%22lastName%22%3A%22Hediyeh-zadeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharon%22%2C%22lastName%22%3A%22Grisaru-Tal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cynthia%22%2C%22lastName%22%3A%22Louis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiutong%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaring%22%2C%22lastName%22%3A%22Schreuder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%22%2C%22lastName%22%3A%22Souza-Fonseca-Guimaraes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%20A.%22%2C%22lastName%22%3A%22de%20Graaf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Thia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Macdonald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary%22%2C%22lastName%22%3A%22Camilleri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kylie%22%2C%22lastName%22%3A%22Luong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shengbo%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Chopin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tristan%22%2C%22lastName%22%3A%22Molden-Hauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%20L.%22%2C%22lastName%22%3A%22Nutt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viktor%22%2C%22lastName%22%3A%22Umansky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bogoljub%22%2C%22lastName%22%3A%22Ciric%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joanna%20R.%22%2C%22lastName%22%3A%22Groom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20S.%22%2C%22lastName%22%3A%22Foster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20M.%22%2C%22lastName%22%3A%22Hansbro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20N.%20J.%22%2C%22lastName%22%3A%22McKenzie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20H.%20D.%22%2C%22lastName%22%3A%22Gray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Behren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Cebon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Vivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ian%20P.%22%2C%22lastName%22%3A%22Wicks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20A.%22%2C%22lastName%22%3A%22Trapani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariel%22%2C%22lastName%22%3A%22Munitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%20J.%22%2C%22lastName%22%3A%22Davis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20J.%22%2C%22lastName%22%3A%22Neeson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabrielle%20T.%22%2C%22lastName%22%3A%22Belz%22%7D%5D%2C%22abstractNote%22%3A%22Group%202%20innate%20lymphoid%20cells%20%28ILC2s%29%20are%20essential%20to%20maintain%20tissue%20homeostasis.%20In%20cancer%2C%20ILC2s%20can%20harbor%20both%20pro-tumorigenic%20and%20anti-tumorigenic%20functions%2C%20but%20we%20know%20little%20about%20their%20underlying%20mechanisms%20or%20whether%20they%20could%20be%20clinically%20relevant%20or%20targeted%20to%20improve%20patient%20outcomes.%20Here%2C%20we%20found%20that%20high%20ILC2%20infiltration%20in%20human%20melanoma%20was%20associated%20with%20a%20good%20clinical%20prognosis.%20ILC2s%20are%20critical%20producers%20of%20the%20cytokine%20granulocyte-macrophage%20colony-stimulating%20factor%2C%20which%20coordinates%20the%20recruitment%20and%20activation%20of%20eosinophils%20to%20enhance%20antitumor%20responses.%20Tumor-infiltrating%20ILC2s%20expressed%20programmed%20cell%20death%20protein-1%2C%20which%20limited%20their%20intratumoral%20accumulation%2C%20proliferation%20and%20antitumor%20effector%20functions.%20This%20inhibition%20could%20be%20overcome%20in%20vivo%20by%20combining%20interleukin-33-driven%20ILC2%20activation%20with%20programmed%20cell%20death%20protein-1%20blockade%20to%20significantly%20increase%20antitumor%20responses.%20Together%2C%20our%20results%20identified%20ILC2s%20as%20a%20critical%20immune%20cell%20type%20involved%20in%20melanoma%20immunity%20and%20revealed%20a%20potential%20synergistic%20approach%20to%20harness%20ILC2%20function%20for%20antitumor%20immunotherapies.%22%2C%22date%22%3A%222021-06-07%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41590-021-00943-z%22%2C%22ISSN%22%3A%221529-2916%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41590-021-00943-z%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22DUPVZUHA%22%5D%2C%22dateModified%22%3A%222021-06-07T16%3A51%3A19Z%22%7D%7D%5D%7D
Jacquelot, N., Seillet, C., Wang, M., Pizzolla, A., Liao, Y., Hediyeh-zadeh, S., Grisaru-Tal, S., Louis, C., Huang, Q., Schreuder, J., Souza-Fonseca-Guimaraes, F., de Graaf, C. A., Thia, K., Macdonald, S., Camilleri, M., Luong, K., Zhang, S., Chopin, M., Molden-Hauer, T., … Belz, G. T. (2021). Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nature Immunology, 1–14. https://doi.org/10.1038/s41590-021-00943-z Cite
