Scientists showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.
[Cancer Research]
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Zhang, Y., Cedervall, J., Hamidi, A., Herre, M., Viitaniemi, K., D’Amico, G., … Olsson, A.-K. (2020). Platelet-specific PDGFB ablation impairs tumor vessel integrity and promotes metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-19-3533 Cite
