JAK Inhibitor Blocks COVID-19-Cytokine-Induced JAK-STAT-APOL1 Signaling in Glomerular Cells and Podocytopathy in Human Kidney Organoids

Based on nine biopsy-proven COVAN cases, researchers demonstrated for the first time that APOL1 protein was abundantly expressed in podocytes and glomerular endothelial cells of COVAN kidneys but not in controls.