In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.
[npj Parkinsons Disease]
1254621
{1254621:DT4U2QZD}
apa
50
1
160673
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ad2ceae4e36cece947928e37d7cc09b4%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22DT4U2QZD%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ramos-Gonzalez%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-30%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERamos-Gonzalez%2C%20P.%2C%20Mato%2C%20S.%2C%20Chara%2C%20J.%20C.%2C%20Verkhratsky%2C%20A.%2C%20Matute%2C%20C.%2C%20%26amp%3B%20Cavaliere%2C%20F.%20%282021%29.%20Astrocytic%20atrophy%20as%20a%20pathological%20feature%20of%20Parkinson%26%23x2019%3Bs%20disease%20with%20LRRK2%20mutation.%20%3Ci%3ENpj%20Parkinson%26%23x2019%3Bs%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%281%29%2C%201%26%23x2013%3B11.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41531-021-00175-w%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41531-021-00175-w%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3DDT4U2QZD%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Astrocytic%20atrophy%20as%20a%20pathological%20feature%20of%20Parkinson%5Cu2019s%20disease%20with%20LRRK2%20mutation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paula%22%2C%22lastName%22%3A%22Ramos-Gonzalez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susana%22%2C%22lastName%22%3A%22Mato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20Carlos%22%2C%22lastName%22%3A%22Chara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexei%22%2C%22lastName%22%3A%22Verkhratsky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlos%22%2C%22lastName%22%3A%22Matute%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabio%22%2C%22lastName%22%3A%22Cavaliere%22%7D%5D%2C%22abstractNote%22%3A%22The%20principal%20hallmark%20of%20Parkinson%5Cu2019s%20disease%20%28PD%29%20is%20the%20selective%20neurodegeneration%20of%20dopaminergic%20neurones.%20Mounting%20evidence%20suggests%20that%20astrocytes%20may%20contribute%20to%20dopaminergic%20neurodegeneration%20through%20decreased%20homoeostatic%20support%20and%20deficient%20neuroprotection.%20In%20this%20study%2C%20we%20generated%20induced%20pluripotent%20stem%20cells%20%28iPSC%29-derived%20astrocytes%20from%20PD%20patients%20with%20LRRK2%28G2019S%29%20mutation%20and%20healthy%20donors%20of%20the%20similar%20age.%20In%20cell%20lines%20derived%20from%20PD%20patients%2C%20astrocytes%20were%20characterised%20by%20a%20significant%20decrease%20in%20S100B%20and%20GFAP-positive%20astrocytic%20profiles%20associated%20with%20marked%20decrease%20in%20astrocyte%20complexity.%20In%20addition%2C%20PD-derived%20astrocytes%20demonstrated%20aberrant%20mitochondrial%20morphology%2C%20decreased%20mitochondrial%20activity%20and%20ATP%20production%20along%20with%20an%20increase%20of%20glycolysis%20and%20increased%20production%20of%20reactive%20oxygen%20species.%20Taken%20together%2C%20our%20data%20indicate%20that%20astrocytic%20asthenia%20observed%20in%20patient-derived%20cultures%20with%20LRRK2%28G2019S%29%20mutation%20may%20contribute%20to%20neuronal%20death%20through%20decreased%20homoeostatic%20support%2C%20elevated%20oxidative%20stress%20and%20failed%20neuroprotection.%22%2C%22date%22%3A%222021-03-30%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41531-021-00175-w%22%2C%22ISSN%22%3A%222373-8057%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41531-021-00175-w%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-30T17%3A21%3A11Z%22%7D%7D%5D%7D
Ramos-Gonzalez, P., Mato, S., Chara, J. C., Verkhratsky, A., Matute, C., & Cavaliere, F. (2021). Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation. Npj Parkinson’s Disease, 7(1), 1–11. https://doi.org/10.1038/s41531-021-00175-w Cite
