Scientists performed histological assays and unbiased single-cell RNA sequencing analysis on cerebral organoids derived from four euploid cell lines and from iPSCs to explore cell type-specific abnormalities associated with Down syndrome during early brain development.
[Journal of Clinical Investigation]
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Tang, X.-Y., Xu, L., Wang, J., Hong, Y., Wang, Y., Zhu, Q., Wang, D., Zhang, X.-Y., Liu, C.-Y., Fang, K.-H., Han, X., Wang, S., Wang, X., Xu, M., Bhattacharyya, A., Guo, X., Lin, M., & Liu, Y. (2021). Suppressing the DSCAM/PAK1 pathway reverses neurogenesis deficits in Down Syndrome patient iPSC-derived cerebral organoids. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI135763 Cite
