The engineered FailSafeTM hPSCs demonstrated robust ventral midbrain specification in vitro, capable of forming neural grafts upon transplantation.
[Nature Communications]
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de Luzy, I. R., Law, K. C. L., Moriarty, N., Hunt, C. P. J., Durnall, J. C., Thompson, L. H., Nagy, A., & Parish, C. L. (2021). Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats. Nature Communications, 12(1), 3275. https://doi.org/10.1038/s41467-021-23125-9 Cite
