Novel Population of Human Monocyte and Osteoclast Progenitors from Pluripotent Stem Cells and Peripheral Blood

The authors developed reproducible methods to derive, from human pluripotent stem cells, a population containing monocyte progenitors able to generate functional osteoclast cells. Within this population, they identified cells with monocyte and osteoclast progenitor activity based on CD11b and CD14 expression.