Leveraging Interacting Signaling Pathways to Robustly Improve the Quality and Yield of Human Pluripotent Stem Cell-Derived Hepatoblasts and Hepatocytes

By leveraging recent knowledge of the signaling pathways involved in liver development, investigators described a robust, scalable protocol that allowed them to consistently generate high-quality bipotent human hepatoblasts and hepatocyte-like cells from both ESCs and iPSCs.