Researchers identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment.
[Nature Cell Biology]
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Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels | Nature Cell Biology. (n.d.). Retrieved June 16, 2020, from https://www.nature.com/articles/s41556-020-0532-x Cite
