Using multiple screening assays upstream and downstream of miR-29a signaling, investigators located the secreted protein and adipogenic inhibitor SPARC to an fibroblast growth factor-2 (FGF-2) signaling pathway that was conserved between skeletal muscle cells from mice and humans and that was activated in skeletal muscle of aged mice and humans.
[Proceedings of the National Academy of Sciences of the United States of America]
7992332
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apa
50
1
166853
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