IFNγ was required for increased expression of the chemokine receptor CCR5 on MΦs. CCR5 antagonism in murine SAA improved survival, correlating with increased platelets and significantly increased platelet-biased CD41hi HSCs.
[Leukemia]
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Seyfried, A. N., McCabe, A., Smith, J. N. P., Calvi, L. M., & MacNamara, K. C. (2021). CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia. Leukemia, 1–13. https://doi.org/10.1038/s41375-021-01219-z Cite
