Inhibition of the cGAS-STING Pathway Ameliorates the Premature Senescence Hallmarks of Ataxia-Telangiectasia Brain Organoids

Scientists showed that the cGAS-STING pathway was required for the recognition of micronuclei and induction of a senescence-associated secretory phenotype in ataxia-telangiectasia olfactory neurosphere-derived cells and brain organoids.