Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment

Investigators evaluated the difference between controls’ and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients’ derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.