Investigators generated rats with medium-grade sepsis with a 30–40% survival rate to study the curative effects of amniotic fluid-MSCs and umbilical cord-MSCs. MSCs reversed cecal ligation and puncture-induced changes in proinflammatory cytokine levels and coagulation activation.
[Stem Cell Research & Therapy]
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Chen, R., Xie, Y., Zhong, X., Chen, F., Gong, Y., Wang, N., & Wang, D. (2021). MSCs derived from amniotic fluid and umbilical cord require different administration schemes and exert different curative effects on different tissues in rats with CLP-induced sepsis. Stem Cell Research & Therapy, 12(1), 164. https://doi.org/10.1186/s13287-021-02218-8 Cite
