Researchers induced human umbilical cord (hUC)-MSCs to differentiate into type 2 alveolar epithelial cells (AEC2s), and provided evidence that intratracheal transplantation of hUC-MSC-derived AEC2s could improve mortality and alleviate fibrosis in bleomycin-induced pulmonary fibrosis mice.
[Stem Cells and Development]
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Liu, J., Peng, D., You, J., Zhou, O., Qiu, H., Hao, C., Chen, H., Fu, Z., & Zou, L. (2021). Type 2 Alveolar Epithelial Cells Differentiated from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Mouse Pulmonary Fibrosis through β-Catenin-Regulated Cell Apoptosis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0208 Cite
