Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
6445218
{6445218:TY3PD2FB}
apa
50
1
161954
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d3e586d5d776f6eee2b9b7b4d7d3bf5b%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22TY3PD2FB%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wei%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-04%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWei%2C%20Q.%2C%20Wang%2C%20Y.%2C%20Ma%2C%20K.%2C%20Li%2C%20Q.%2C%20Li%2C%20B.%2C%20Hu%2C%20W.%2C%20Fu%2C%20X.%2C%20%26amp%3B%20Zhang%2C%20C.%20%282021%29.%20Extracellular%20Vesicles%20from%20Human%20Umbilical%20Cord%20Mesenchymal%20Stem%20Cells%20Facilitate%20Diabetic%20Wound%20Healing%20Through%20MiR-17-5p-mediated%20Enhancement%20of%20Angiogenesis.%20%3Ci%3EStem%20Cell%20Reviews%20and%20Reports%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs12015-021-10176-0%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs12015-021-10176-0%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DTY3PD2FB%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extracellular%20Vesicles%20from%20Human%20Umbilical%20Cord%20Mesenchymal%20Stem%20Cells%20Facilitate%20Diabetic%20Wound%20Healing%20Through%20MiR-17-5p-mediated%20Enhancement%20of%20Angiogenesis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qian%22%2C%22lastName%22%3A%22Wei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yaxi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kui%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiankun%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bingmin%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenzhi%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaobing%22%2C%22lastName%22%3A%22Fu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cuiping%22%2C%22lastName%22%3A%22Zhang%22%7D%5D%2C%22abstractNote%22%3A%22Endothelial%20dysfunction%20caused%20by%20persistent%20hyperglycemia%20in%20diabetes%20is%20responsible%20for%20impaired%20angiogenesis%20in%20diabetic%20wounds.%20Extracellular%20vehicles%20%28EVs%29%20are%20considered%20potential%20therapeutic%20tools%20to%20promote%20diabetic%20wound%20healing.%20The%20aim%20of%20this%20study%20was%20to%20investigate%20the%20effects%20of%20EVs%20secreted%20by%20human%20umbilical%20cord%20mesenchymal%20stem%20cells%20%28hucMSC-EVs%29%20on%20angiogenesis%20under%20high%20glucose%20%28HG%29%20conditions%20in%20vivo%20and%20in%20vitro%20and%20to%20explore%20the%20underlying%20mechanisms.%20In%20vivo%2C%20local%20application%20of%20hucMSC-EVs%20enhanced%20wound%20healing%20and%20angiogenesis.%20In%20vitro%2C%20hucMSC-EVs%20promoted%20proliferation%2C%20migration%2C%20and%20tube%20formation%20by%20inhibiting%20phosphatase%20and%20tensin%20homolog%20%28PTEN%29%20expression%20and%20activating%20the%20AKT%5C%2FHIF-1%5Cu03b1%5C%2FVEGF%20pathways.%20MiR-17-5p%20was%20found%20to%20be%20highly%20enriched%20in%20hucMSC-EVs.%20In%20vitro%2C%20MiR-17-5p%20agomirs%20downregulated%20the%20expression%20of%20PTEN%20and%20activated%20the%20AKT%5C%2FHIF-1%5Cu03b1%5C%2FVEGF%20pathway%20to%20promote%20proliferation%2C%20migration%2C%20and%20tube%20formation%20in%20HG-treated%20HUVECs.%20In%20vivo%2C%20miR-17-5p%20agomirs%20mimicked%20the%20effects%20of%20hucMSC-EVs%20on%20wound%20healing%20and%20angiogenesis%2C%20whereas%20miR-17-5p%20inhibitors%20reversed%20their%20effects.%20Our%20findings%20suggest%20that%20hucMSC-EVs%20have%20regenerative%20and%20protective%20effects%20on%20HG-induced%20endothelial%20cells%20via%20transfer%20of%20miR-17-5p%20targeting%20PTEN%5C%2F%20AKT%5C%2FHIF-1%5Cu03b1%5C%2FVEGF%20pathway%2C%20thereby%20accelerating%20diabetic%20wound%20healing.%20Thus%2C%20hucMSC-EVs%20may%20be%20promising%20therapeutic%20candidates%20for%20improving%20diabetic%20wound%20angiogenesis.%22%2C%22date%22%3A%222021-05-04%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs12015-021-10176-0%22%2C%22ISSN%22%3A%222629-3277%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs12015-021-10176-0%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-06T17%3A57%3A47Z%22%7D%7D%5D%7D
Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
