Both placental-derived allogeneic preparations, cord blood platelet lysate and amniotic membrane extract eye drops, display regenerative and immunomodulatory capabilities.
[Scientific Reports]
6445218
{6445218:CDPR6XLS}
apa
50
1
164112
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-0b4424956428130d6e2fed390494fcb2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22CDPR6XLS%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Samarkanova%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-02%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESamarkanova%2C%20D.%2C%20Cox%2C%20S.%2C%20Hernandez%2C%20D.%2C%20Rodriguez%2C%20L.%2C%20P%26%23xE9%3Brez%2C%20M.%20L.%2C%20Madrigal%2C%20A.%2C%20Vilarrodona%2C%20A.%2C%20Querol%2C%20S.%2C%20%26amp%3B%20Casaroli-Marano%2C%20R.%20P.%20%282021%29.%20Cord%20blood%20and%20amniotic%20membrane%20extract%20eye%20drop%20preparations%20display%20immune-suppressive%20and%20regenerative%20properties.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2013754.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-93150-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-93150-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DCDPR6XLS%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cord%20blood%20and%20amniotic%20membrane%20extract%20eye%20drop%20preparations%20display%20immune-suppressive%20and%20regenerative%20properties%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dinara%22%2C%22lastName%22%3A%22Samarkanova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%22%2C%22lastName%22%3A%22Hernandez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luciano%22%2C%22lastName%22%3A%22Rodriguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Luisa%22%2C%22lastName%22%3A%22P%5Cu00e9rez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%22%2C%22lastName%22%3A%22Madrigal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Vilarrodona%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergio%22%2C%22lastName%22%3A%22Querol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ricardo%20P.%22%2C%22lastName%22%3A%22Casaroli-Marano%22%7D%5D%2C%22abstractNote%22%3A%22Diseases%20and%20injuries%20that%20compromise%20the%20ocular%20surface%20cause%20considerable%20patient%20distress%20and%20have%20long%20term%20consequences%20for%20their%20quality%20of%20life.%20Treatment%20modalities%20that%20can%20address%20the%20delicate%20balance%20of%20tissue%20regeneration%2C%20inflammation%20and%20maintenance%20of%20corneal%20transparency%20are%20therefore%20needed.%20We%20have%20recently%20formulated%20two%20novel%20eye%20drops%20from%20placental%20tissues%3A%20cord%20blood%20platelet%20lysate%20%28CBED%29%20and%20amniotic%20membrane%20extract%20eye%20drops%20%28AMED%29%2C%20which%20can%20be%20used%20to%20treat%20severe%20ocular%20disorders.%20Here%20we%20characterise%20these%20two%20preparations%20by%20measuring%3A%20%28a%29%20growth%20factors%20%28GF%29%20and%20cytokines%20composition%2C%20%28b%29%20promotion%20of%20human%20corneal%20epithelial%20cell%20%28HCEC%29%20growth%20and%20%28c%29%20effects%20on%20immune%20cells%20in%20a%20lymphocyte%20culture%20assay.%20Finally%2C%20their%20bioavailability%20was%20assayed%20in%20an%20ex%20vivo%20porcine%20corneal%20model.%20We%20show%20that%20both%20preparations%20contain%20GF%20and%20cytokines%20that%20were%20able%20to%20promote%20the%20in%20vitro%20growth%20of%20HCEC%20and%20support%20repair%20in%20an%20in%20vitro%20scratch%20test.%20When%20assessed%20in%20a%20lymphocyte%20culture%2C%20both%20favoured%20immune%20suppression%20reducing%20the%20cellular%20expression%20of%20NKG2D%20and%20CD107a%20as%20well%20as%20the%20production%20of%20interferon%20gamma%20%28IFN-%5Cu03b3%29%20in%20natural%20killer%2C%20NKT%20and%20T%20cells.%20Regarding%20bioavailability%2C%20CBED%20active%20molecules%20were%20found%20mainly%20in%20the%20pre-corneal%20fraction%20with%20some%20penetration%20into%20the%20corneal%20fraction%2C%20in%20an%20ex%20vivo%20model.%20In%20summary%2C%20both%20placental-derived%20allogeneic%20preparations%2C%20CBED%20and%20AMED%2C%20display%20regenerative%20and%20immunomodulatory%20capabilities.%20These%20results%20will%20help%20define%20mechanisms%20of%20action%20and%20the%20best%20indications%20and%20doses%20of%20each%20product%20for%20use%20in%20a%20particular%20patient%20and%20support%20the%20development%20of%20off-the-shelf%20therapies%20for%20ocular%20surface%20pathologies%20in%20which%20wound%20healing%20defects%20and%20inflammatory%20events%20are%20contributing%20factors.%22%2C%22date%22%3A%222021-07-02%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-93150-7%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-93150-7%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-02T17%3A15%3A14Z%22%7D%7D%5D%7D
Samarkanova, D., Cox, S., Hernandez, D., Rodriguez, L., Pérez, M. L., Madrigal, A., Vilarrodona, A., Querol, S., & Casaroli-Marano, R. P. (2021). Cord blood and amniotic membrane extract eye drop preparations display immune-suppressive and regenerative properties. Scientific Reports, 11(1), 13754. https://doi.org/10.1038/s41598-021-93150-7 Cite
