Home Newsletters Umbilical & Placental Cell News Exosomal microRNA-1246 from Human Umbilical Cord Mesenchymal Stem Cells Potentiates Myocardial Angiogenesis...

Exosomal microRNA-1246 from Human Umbilical Cord Mesenchymal Stem Cells Potentiates Myocardial Angiogenesis in Chronic Heart Failure

0
Cardiac function, myocardial infarction area, apoptosis, and angiogenesis were all evaluated in a CHF rat model following treatment with human umbilical cord MSC-derived exosomes.
[Cell Biology International]
6445218 {6445218:KX2QFRN3} apa 50 1 164916 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-5269e98d95c1b59e598b93408a938951%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22KX2QFRN3%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wang%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWang%2C%20Z.%2C%20Gao%2C%20D.%2C%20Wang%2C%20S.%2C%20Lin%2C%20H.%2C%20Wang%2C%20Y.%2C%20%26amp%3B%20Xu%2C%20W.%20%28n.d.%29.%20Exosomal%20microRNA-1246%20from%20human%20umbilical%20cord%20mesenchymal%20stem%20cells%20potentiates%20myocardial%20angiogenesis%20in%20chronic%20heart%20failure.%20%3Ci%3ECell%20Biology%20International%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcbin.11664%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcbin.11664%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DKX2QFRN3%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Exosomal%20microRNA-1246%20from%20human%20umbilical%20cord%20mesenchymal%20stem%20cells%20potentiates%20myocardial%20angiogenesis%20in%20chronic%20heart%20failure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zicheng%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Da%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shengjie%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haiyan%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanwei%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Weifeng%22%2C%22lastName%22%3A%22Xu%22%7D%5D%2C%22abstractNote%22%3A%22ABSTRACTMicroRNAs%20%28miRNAs%29%20are%20of%20importance%20to%20chronic%20heart%20failure%20%28CHF%29.%20However%2C%20the%20relevance%20of%20the%20exosomal%20miRNAs%20produced%20during%20CHF%20remains%20unknown.%20Our%20purpose%20here%20was%20to%20examine%20the%20relevance%20of%20exosomal%20miR-1246%20released%20from%20human%20umbilical%20cord%20mesenchymal%20stem%20cell%20%28hucMSC%29%20during%20CHF%20and%20the%20mechanism%20of%20action.%20Cardiac%20function%2C%20myocardial%20infarction%20area%2C%20apoptosis%2C%20and%20angiogenesis%20were%20all%20evaluated%20in%20a%20CHF%20rat%20model%20following%20treatment%20with%20hucMSC-derived%20exosomes%20%28hucMSC-Exos%29.%20H9C2%20and%20human%20umbilical%20vascular%20endothelial%20cells%20%28HUVECs%29%20were%20subjected%20to%20oxygen%20and%20glucose%20deprivation%20and%20exosome%20treatment%20to%20quantify%20the%20cell%20proliferation%20and%20apoptosis%20in%20H9C2%20cells%20and%20the%20tube%20formation%20capacity%20of%20the%20HUVECs.%20A%20dual-luciferase%20activity%20reporter%20assay%20was%20conducted%20to%20validate%20the%20interaction%20between%20miR-1246%20and%20serine%20protease%2023%20%28PRSS23%29.%20HucMSCs%20treatment%20led%20to%20a%20reduction%20in%20H9C2%20apoptosis%20and%20an%20increase%20in%20HUVEC%20angiogenesis%2C%20which%20were%20mitigated%20when%20hucMSCs%20were%20treated%20with%20an%20miR-1246%20inhibitor.%20We%20also%20confirmed%20that%20PRSS23%20is%20a%20putative%20target%20of%20miR-1246%20and%20that%20miR-1246%20attenuated%20hypoxia-induced%20myocardial%20tissue%20damage%20by%20targeting%20PRSS23%20and%20inhibiting%20the%20activation%20of%20the%20Snail%5C%2F%5Cu03b1-SMA%20signaling.%20Our%20findings%20suggest%20that%20exosomal%20miR-1246%20from%20hucMSCs%20protects%20the%20heart%20from%20failure%20by%20targeting%20PRSS23.This%20article%20is%20protected%20by%20copyright.%20All%20rights%20reserved.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fcbin.11664%22%2C%22ISSN%22%3A%221095-8355%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fcbin.11664%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-22T19%3A33%3A36Z%22%7D%7D%5D%7D
Wang, Z., Gao, D., Wang, S., Lin, H., Wang, Y., & Xu, W. (n.d.). Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11664 Cite
Abstract
Exit mobile version