The human umbilical cord MSC exosomes were found to effectively improve the viability of nucleus pulposus cells and protect them from pyroptosis through targeting METTL14, with a methyltransferase catalyzing m6A modification.
[Molecular Medicine]
6445218
{6445218:DB6PQEDW}
apa
50
1
166046
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d9f589de29d285dcdec4dd36c1026832%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22DB6PQEDW%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Yuan%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-19%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EYuan%2C%20X.%2C%20Li%2C%20T.%2C%20Shi%2C%20L.%2C%20Miao%2C%20J.%2C%20Guo%2C%20Y.%2C%20%26amp%3B%20Chen%2C%20Y.%20%282021%29.%20Human%20umbilical%20cord%20mesenchymal%20stem%20cells%20deliver%20exogenous%20miR-26a-5p%20via%20exosomes%20to%20inhibit%20nucleus%20pulposus%20cell%20pyroptosis%20through%20METTL14%5C%2FNLRP3.%20%3Ci%3EMolecular%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E27%3C%5C%2Fi%3E%281%29%2C%2091.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs10020-021-00355-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs10020-021-00355-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DDB6PQEDW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Human%20umbilical%20cord%20mesenchymal%20stem%20cells%20deliver%20exogenous%20miR-26a-5p%20via%20exosomes%20to%20inhibit%20nucleus%20pulposus%20cell%20pyroptosis%20through%20METTL14%5C%2FNLRP3%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoqiu%22%2C%22lastName%22%3A%22Yuan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiefeng%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lei%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinhao%22%2C%22lastName%22%3A%22Miao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yongfei%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yu%22%2C%22lastName%22%3A%22Chen%22%7D%5D%2C%22abstractNote%22%3A%22Intervertebral%20disc%20degeneration%20%28IVDD%29%20is%20the%20breakdown%20of%20the%20discs%20supporting%20the%20vertebrae.%20It%20is%20one%20of%20the%20most%20frequent%20causes%20of%20back%20pain%20worldwide.%20Currently%2C%20the%20clinical%20interventions%20for%20IVDD%20are%20mainly%20focused%20on%20symptom%20releases.%20Thus%2C%20new%20therapeutic%20options%20are%20needed.%22%2C%22date%22%3A%22August%2019%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs10020-021-00355-7%22%2C%22ISSN%22%3A%221528-3658%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs10020-021-00355-7%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-20T20%3A46%3A37Z%22%7D%7D%5D%7D
Yuan, X., Li, T., Shi, L., Miao, J., Guo, Y., & Chen, Y. (2021). Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3. Molecular Medicine, 27(1), 91. https://doi.org/10.1186/s10020-021-00355-7 Cite
