Researchers investigated the safety for clinic use and therapeutic effects of basic fibroblast growth factor-overexpressing human umbilical cord-derived MSCs in mice with completely transected spinal cord injury.
[Stem Cell Research & Therapy]
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Huang, F., Gao, T., Wang, W., Wang, L., Xie, Y., Tai, C., Liu, S., Cui, Y., & Wang, B. (2021). Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway. Stem Cell Research & Therapy, 12(1), 468. https://doi.org/10.1186/s13287-021-02537-w Cite
