Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
NIH to Prioritize Human-Based Research Technologies
[NIH] The NIH is adopting a new initiative to expand innovative, human-based science while reducing animal use in research. Developing and using cutting-edge alternative nonanimal research models aligns with the US FDA's recent initiative to reduce testing in animals.
Crown Bioscience and NEXT Oncology Cement Partnership Extension
[Crown Bioscience] Crown Bioscience announced the extension of its partnership with NEXT Oncology to leverage Crown Bioscience's extensive experience in developing clinically relevant cancer organoid and patient-derived xenograft models, together with NEXT Oncology's global clinical network and Phase I clinical trials expertise.
Specification of Human Brain Regions with Orthogonal Gradients of WNT and SHH in Organoids Reveals Patterning Variations across Cell Lines
[Cell Stem Cell] The authors designed the Dual Orthogonal-Morphogen Assisted Patterning System (Duo-MAPS) diffusion device to expose spheres of iPSCs to concomitant orthogonal gradients of a posteriorizing and a ventralizing morphogen, activating WNT and SHH signaling, respectively.
Patient-Derived Models of UBA5-Associated Encephalopathy Identify Defects in Neurodevelopment and Highlight Potential Therapeutic Avenues
[Science Translational Medicine] Investigators developed and characterized patient-derived cortical organoid cultures from two patients with compound heterozygous variants in UBA5.
Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Novel Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery
[Molecular Psychiatry] Scientists developed a complex hPSC-based vascularized neuroimmune organoid model, which contains multiple cell types affected in human Alzheimer's disease brains, including human neurons, microglia, astrocytes, and blood vessels.
YAP/TAZ Activity in PDGFRα-expressing Alveolar Fibroblasts Modulates AT2 Proliferation through Wnt4
[Cell Reports] Researchers engineered a mouse model for the inducible knockdown of yes-associated protein 1 (YAP)/WW-domain-containing transcription regulator 1 (TAZ) and showed that fibroblast-specific knockdown enhances PDGFRα+ alveolar fibroblasts’ support for alveolar-epithelial-stem-cell-derived organoids in vitro.
Establishment and Characterization of 24 Breast Cancer Cell Lines and 3 Breast Cancer Organoids Reveals Molecular Heterogeneity and Drug Response Variability in Malignant Pleural...
[Breast Cancer Research] Investigators investigate the molecular heterogeneity of breast cancer cells derived from malignant pleural effusions to understand variations in drug resistance and cellular evolution.
Docosahexaenoic Acid Prevents Peroxisomal and Mitochondrial Protein Loss in a Murine Hepatic Organoid Model of Severe Malnutrition
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Using a previously established murine hepatic organoid model of severe malnutrition, researchers characterized the effects of prolonged amino-acid restriction on peroxisomal and mitochondrial protein levels and on autophagic flux.
P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids
[Cancer Research Communications] Using human pancreatic ductal adenocarcinoma organoids, the authors determined that hypoxia consistently enhanced invasion across 11 patient-derived models.
Integrating Collecting Systems in Human Kidney Organoids through Fusion of Distal Nephron to Ureteric Bud
[Cell Stem Cell] Human kidney organoids derived from hPSCs generate nephrons that lack collecting ducts and terminate as blind-ended tubules. Scientists describe a developmentally inspired hPSC differentiation system that addresses this deficiency through assembly of induced nephrogenic mesenchyme with ureteric bud progenitors.
A Retinoic Acid:YAP1 Signaling Axis Controls Atrial Lineage Commitment
[Cell Reports] The authors applied a functional genomics approach to untreated and RA-treated hESC-derived cardiac progenitor cells.
Bioengineering Innovations for Neural Organoids with Enhanced Fidelity and Function
[Cell Stem Cell] Investigators discuss emerging bioengineering approaches that control morphogen signals and biophysical microenvironments, which have improved the efficiency, fidelity, and utility of neural organoids.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
