Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Pancreatic Exocrine Damage Induces Beta Cell Stress in Zebrafish Larvae
[Diabetologia] To explore the impact of exocrine damage on beta cell fitness, scientists generated a novel zebrafish model allowing exocrine pancreas ablation, using a nifurpirinol–nitroreductase system.
SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling
[Advanced Science] The authors revealed that the voltage-gated calcium channel subunit α2δ1-mediated calcium signaling could upregulate the expression of SIRT4, which was highly expressed in α2δ1-positive pancreatic tumor-initiating cells.
Brown Lab Awarded Grant to Study Potential New Treatment for Type 1 Diabetes
[University of Wisconsin School of Medicine and Public Health] With a new two-year, $700,000 grant from Breakthrough T1D, Dr. Matthew E. Brown and his team will be creating and studying hypoimmune, insulin-producing, stem cell-derived islet-like clusters as a potential new treatment for T1D.
Molecular Mapping and Functional Validation of GLP-1R Cholesterol Binding Sites in Pancreatic Beta Cells
[elife] The authors unveiled the detrimental effect of a high cholesterol diet on glucagon-like peptide-1 receptor (GLP-1R)-dependent glucoregulation in vivo, and the improvement in GLP-1R function that a reduction in cholesterol synthesis using simvastatin exerts in pancreatic islets.
Glycine Receptor Activation Promotes Pancreatic Islet Cell Proliferation via the PI3K/mTORC1/p70S6K Pathway
[JCI Insight] In vitro experiments on mouse and human islets revealed that glycine and β-alanine, via GlyR activation, stimulated the proliferation of β cells and α cells, without affecting insulin or glucagon secretion.
Spatial Mapping of Transcriptomic Plasticity in Metastatic Pancreatic Cancer
[Nature] Researchers constructed high-resolution maps of lineage states, clonal architecture, and the tumor microenvironment using spatially resolved transcriptomics from 55 samples of primary tumor and metastases collected from rapid autopsies of 13 people.
RFX3 Is Essential for the Generation of Functional Human Pancreatic Islets from Stem Cells
[Diabetologia] Scientists generated regulatory factor X 3 (RFX3) knockout iPSC lines using CRISPR/Cas9 and differentiated them into pancreatic islet organoids.
Targeting PIKfyve-Driven Lipid Metabolism in Pancreatic Cancer
[Nature] The authors characterized PIKfyve, a lipid kinase that was integral to lysosomal functioning7, as a targetable vulnerability in PDAC.
Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes
[Nature Communications] Scientists constructed a genome-wide protein quantitative trait loci map of 1985 proteins in 695 newborn babies at increased genetic risk of developing type 1 diabetes.
Macrophages and Fibroblasts As Regulators of the Immune Response in Pancreatic Cancer
[Nature Immunology] Scientists provide an overview of the heterogeneity of cancer-associated fibroblasts and tumor-associated macrophages, how they establish an immunosuppressive microenvironment and their collaboration in the remodeling of the ECM.
Advancing toward a Curative Frontier: An Updated Narrative Review on Stem-Cell Therapy in Pediatric Type 1 Diabetes
[World Journal of Pediatrics] A comprehensive review of the literature was conducted to evaluate stem-cell types: embryonic, perinatal, adult, induced pluripotent and cancer stem cells, and their role in T1D treatment.
Gold Nanoparticle Resveratrol Complex Increases Apoptosis in KRAS Mutant Pancreatic Cancer Cells
[Scientific Reports] To enhance delivery rate and efficacy, the size of about 30 nm gold nanoparticles was synthesized and conjugated to resveratrol via polyvinylpyrrolidone for high bioavailability.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
