Researchers identified TBC1D15-mediated oncogenic mechanisms and tested the tumorigenic roles of TBC1D15 in vivo.
[Nature Communications]
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Choi, H. Y., Siddique, H. R., Zheng, M., Kou, Y., Yeh, D.-W., Machida, T., Chen, C.-L., Uthaya Kumar, D. B., Punj, V., Winer, P., Pita, A., Sher, L., Tahara, S. M., Ray, R. B., Liang, C., Chen, L., Tsukamoto, H., & Machida, K. (2020). p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. Nature Communications, 11(1), 3084. https://doi.org/10.1038/s41467-020-16616-8 Cite
