From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.
[British Journal of Cancer]
1254621
WV8KWX9L
items
1
apa
0
default
asc
1
150998
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d3e58f7e6346b30613b5048e173bd843%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22WV8KWX9L%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Morvan%20et%20al.%22%2C%22parsedDate%22%3A%222020-06-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMorvan%2C%20V.%20L.%2C%20Richard%2C%20%26%23xC9%3B.%2C%20Cadars%2C%20M.%2C%20Fessart%2C%20D.%2C%20Broca-Brisson%2C%20L.%2C%20Auzanneau%2C%20C.%2C%20Pasquies%2C%20A.%2C%20Modesto%2C%20A.%2C%20Lusque%2C%20A.%2C%20Mathoulin-P%26%23xE9%3Blissier%2C%20S.%2C%20Lansiaux%2C%20A.%2C%20%26amp%3B%20Robert%2C%20J.%20%282020%29.%20Cytochrome%20P450%201B1%20polymorphism%20drives%20cancer%20cell%20stemness%20and%20patient%20outcome%20in%20head-and-neck%20carcinoma.%20%3Ci%3EBritish%20Journal%20of%20Cancer%3C%5C%2Fi%3E%2C%201%26%23x2013%3B13.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41416-020-0932-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41416-020-0932-5%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3DWV8KWX9L%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cytochrome%20P450%201B1%20polymorphism%20drives%20cancer%20cell%20stemness%20and%20patient%20outcome%20in%20head-and-neck%20carcinoma%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9rie%20Le%22%2C%22lastName%22%3A%22Morvan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu00c9lodie%22%2C%22lastName%22%3A%22Richard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maud%22%2C%22lastName%22%3A%22Cadars%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Fessart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9a%22%2C%22lastName%22%3A%22Broca-Brisson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9line%22%2C%22lastName%22%3A%22Auzanneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Pasquies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anouchka%22%2C%22lastName%22%3A%22Modesto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00e9lie%22%2C%22lastName%22%3A%22Lusque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Mathoulin-P%5Cu00e9lissier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00e9lie%22%2C%22lastName%22%3A%22Lansiaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacques%22%2C%22lastName%22%3A%22Robert%22%7D%5D%2C%22abstractNote%22%3A%22Cytochrome%20P450%201B1%20%28CYP1B1%29%20is%20mostly%20expressed%20in%20tumours%20and%20displays%20unusual%20properties.%20Its%20two%20polymorphic%20forms%20were%20differently%20associated%20with%20anticancer%20drug%20sensitivity.%20We%20decipher%20here%20the%20role%20of%20this%20polymorphism%20in%20anticancer%20drug%20efficacy%20in%20vitro%2C%20in%20vivo%20and%20in%20the%20clinical%20setting.%22%2C%22date%22%3A%222020-06-22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41416-020-0932-5%22%2C%22ISSN%22%3A%221532-1827%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41416-020-0932-5%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-06-22T17%3A07%3A03Z%22%7D%7D%5D%7D
Morvan, V. L., Richard, É., Cadars, M., Fessart, D., Broca-Brisson, L., Auzanneau, C., Pasquies, A., Modesto, A., Lusque, A., Mathoulin-Pélissier, S., Lansiaux, A., & Robert, J. (2020). Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-020-0932-5 Cite
