Investigators showed that Zeb1 is an important factor promoting vascular endothelial cell (EC) proliferation and corneal neovascularization (NV); and a couple of small molecule inhibitors can evict Ctbp from the Zeb1–Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV.
[Communications Biology]
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Jin, L., Zhang, Y., Liang, W., Lu, X., Piri, N., Wang, W., … Liu, Y. (2020). Zeb1 promotes corneal neovascularization by regulation of vascular endothelial cell proliferation. Communications Biology, 3(1), 1–10. https://doi.org/10.1038/s42003-020-1069-z Cite
