In three dimensional organotypic assays, peptide-exposed telomerase immortalised fibroblasts and primary cancer-associated fibroblasts from breast carcinoma patients both exhibited a markedly reduced pro-invasive ability of either HT1080 fibrosarcoma or MDA-MB-231 mammary carcinoma cells, respectively.
[Cancers]
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Belli, S., Franco, P., Iommelli, F., De Vincenzo, A., Brancaccio, D., Telesca, M., Merlino, F., Novellino, E., Ranson, M., Del Vecchio, S., Grieco, P., Carotenuto, A., & Stoppelli, M. P. (2020). Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides. Cancers, 12(9), 2404. https://doi.org/10.3390/cancers12092404 Cite
