Investigators showed that pharmacological inhibition of BRAF-V600E or ERK1/2 in melanoma cells increased PARK2 expression.
[Journal of Biological Chemistry]
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Montagnani, V., Maresca, L., Apollo, A., Pepe, S., Carr, R. M., Fernandez-Zapico, M. E., & Stecca, B. (2020). E3 ubiquitin ligase PARK2, an inhibitor of melanoma cell growth, is repressed by the oncogenic ERK1/2-ELK1 transcriptional axis. Journal of Biological Chemistry, jbc.RA120.014615. https://doi.org/10.1074/jbc.RA120.014615 Cite
