Using mice with inducible intestinal epithelial cell-specific deletion of Phb1 and mice with IEC-specific overexpression of Phb1, investigators demonstrated that IEC-specific PHB1 combats intestinal tumorigenesis in the ApcMin/+ mouse model by inhibiting Wnt/β-catenin signaling.
[Oncogene]
6606345
{6606345:WIE9BFKS}
apa
50
1
156002
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-4baa284b019357da3d2c77664cae0351%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22WIE9BFKS%22%2C%22library%22%3A%7B%22id%22%3A6606345%7D%2C%22meta%22%3A%7B%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Ci%3ENuclear%20partitioning%20of%20Prohibitin%201%20inhibits%20Wnt%5C%2F%26%23x3B2%3B-catenin-dependent%20intestinal%20tumorigenesis%20%7C%20Oncogene%3C%5C%2Fi%3E.%20%28n.d.%29.%20Retrieved%20November%206%2C%202020%2C%20from%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41388-020-01538-y%27%3Ehttps%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41388-020-01538-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6606345%26amp%3Bitem_key%3DWIE9BFKS%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Nuclear%20partitioning%20of%20Prohibitin%201%20inhibits%20Wnt%5C%2F%5Cu03b2-catenin-dependent%20intestinal%20tumorigenesis%20%7C%20Oncogene%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41388-020-01538-y%22%2C%22language%22%3A%22%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-11-06T21%3A15%3A49Z%22%7D%7D%5D%7D
Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis | Oncogene. (n.d.). Retrieved November 6, 2020, from https://www.nature.com/articles/s41388-020-01538-y Cite
