Investigators found that reprogramming transcription during hematopoietic differentiation resulted in an overload of genotoxic stress, which caused aborted differentiation and depletion of Fanconi anemia mutant progenitor cells.
[Molecular Cell]
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Shen, X., Wang, R., Kim, M. J., Hu, Q., Hsu, C.-C., Yao, J., Klages-Mundt, N., Tian, Y., Lynn, E., Brewer, T. F., Zhang, Y., Arun, B., Gan, B., Andreeff, M., Takeda, S., Chen, J., Park, J., Shi, X., Chang, C. J., … Li, L. (2020). A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Molecular Cell, 80(6), 1013-1024.e6. https://doi.org/10.1016/j.molcel.2020.11.040 Cite
