Investigators showed that MITF, the master transcription factor in melanocytes, controls ubiquitination in melanoma cells. They identified FBXO32, a component of the SCF E3 ligase complex as a new MITF target gene.
[Cell Death & Differentiation]
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Habel, N., El-Hachem, N., Soysouvanh, F., Hadhiri-Bzioueche, H., Giuliano, S., Nguyen, S., Horák, P., Gay, A.-S., Debayle, D., Nottet, N., Béranger, G., Paillerets, B. B., Bertolotto, C., & Ballotti, R. (2021). FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells. Cell Death & Differentiation, 1–12. https://doi.org/10.1038/s41418-020-00710-x Cite
