Using a Lgr5-2A-DTR model, which ablates Lgr5+ cells with near-complete efficiency and retains endogenous levels of Lgr5 expression, researchers showed that persistent depletion of Lgr5+ intestinal stem cells in fact compromised small intestinal epithelial integrity and reduced epithelial turnover in vivo.
[Cell Reports]
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Tan, S. H., Phuah, P., Tan, L. T., Yada, S., Goh, J., Tomaz, L. B., Chua, M., Wong, E., Lee, B., & Barker, N. (2021). A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108633 Cite
