Researchers conducted a pooled CRISPR screen in human hematopoietic stem and progenitor cells that correlated ELANE mutations with neutrophil maturation potential.
[Cell Stem Cell]
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Rao, S., Yao, Y., Brito, J. S. de, Yao, Q., Shen, A. H., Watkinson, R. E., Kennedy, A. L., Coyne, S., Ren, C., Zeng, J., Serbin, A. V., Studer, S., Ballotti, K., Harris, C. E., Luk, K., Stevens, C. S., Armant, M., Pinello, L., Wolfe, S. A., … Bauer, D. E. (2021). Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.12.015 Cite
