Home Newsletters Neural Cell News Single-Cell Atlas of Developing Murine Adrenal Gland Reveals Relation of Schwann Cell...

Single-Cell Atlas of Developing Murine Adrenal Gland Reveals Relation of Schwann Cell Precursor Signature to Neuroblastoma Phenotype

0
Investigators provided an insight into the developing adrenal gland and introduced the Schwann cell precursor gene signature as being of interest for further research in understanding neuroblastoma phenotype.
[Proceedings of the National Academy of Sciences of the United States of America]
6807162 {6807162:82FAMN84} apa 50 1 158578 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-535e07dd317c6da7a83355cc027d0be8%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2282FAMN84%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hanemaaijer%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHanemaaijer%2C%20E.%20S.%2C%20Margaritis%2C%20T.%2C%20Sanders%2C%20K.%2C%20Bos%2C%20F.%20L.%2C%20Candelli%2C%20T.%2C%20Al-Saati%2C%20H.%2C%20Noesel%2C%20M.%20M.%20van%2C%20Meyer-Wentrup%2C%20F.%20A.%20G.%2C%20Wetering%2C%20M.%20van%20de%2C%20Holstege%2C%20F.%20C.%20P.%2C%20%26amp%3B%20Clevers%2C%20H.%20%282021%29.%20Single-cell%20atlas%20of%20developing%20murine%20adrenal%20gland%20reveals%20relation%20of%20Schwann%20cell%20precursor%20signature%20to%20neuroblastoma%20phenotype.%20%3Ci%3EProceedings%20of%20the%20National%20Academy%20of%20Sciences%3C%5C%2Fi%3E%2C%20%3Ci%3E118%3C%5C%2Fi%3E%285%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2022350118%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2022350118%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D82FAMN84%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Single-cell%20atlas%20of%20developing%20murine%20adrenal%20gland%20reveals%20relation%20of%20Schwann%20cell%20precursor%20signature%20to%20neuroblastoma%20phenotype%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evelyn%20S.%22%2C%22lastName%22%3A%22Hanemaaijer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thanasis%22%2C%22lastName%22%3A%22Margaritis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%22%2C%22lastName%22%3A%22Sanders%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%20L.%22%2C%22lastName%22%3A%22Bos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tito%22%2C%22lastName%22%3A%22Candelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanin%22%2C%22lastName%22%3A%22Al-Saati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%20M.%20van%22%2C%22lastName%22%3A%22Noesel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Friederike%20A.%20G.%22%2C%22lastName%22%3A%22Meyer-Wentrup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%20van%20de%22%2C%22lastName%22%3A%22Wetering%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%20C.%20P.%22%2C%22lastName%22%3A%22Holstege%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%22%2C%22lastName%22%3A%22Clevers%22%7D%5D%2C%22abstractNote%22%3A%22Neuroblastoma%20is%20the%20most%20common%20extracranial%20solid%20tumor%20and%20accounts%20for%20%5Cu223c10%25%20of%20pediatric%20cancer-related%20deaths.%20The%20exact%20cell%20of%20origin%20has%20yet%20to%20be%20elucidated%2C%20but%20it%20is%20generally%20accepted%20that%20neuroblastoma%20derives%20from%20the%20neural%20crest%20and%20should%20thus%20be%20considered%20an%20embryonal%20malignancy.%20About%2050%25%20of%20primary%20neuroblastoma%20tumors%20arise%20in%20the%20adrenal%20gland.%20Here%2C%20we%20present%20an%20atlas%20of%20the%20developing%20mouse%20adrenal%20gland%20at%20a%20single-cell%20level.%20Five%20main%20cell%20cluster%20groups%20%28medulla%2C%20cortex%2C%20endothelial%2C%20stroma%2C%20and%20immune%29%20make%20up%20the%20mouse%20adrenal%20gland%20during%20fetal%20development.%20The%20medulla%20group%2C%20which%20is%20of%20neural%20crest%20origin%2C%20is%20further%20divided%20into%20seven%20clusters.%20Of%20interest%20is%20the%20Schwann%20cell%20precursor%20%28%5Cu201cSCP%5Cu201d%29%20and%20the%20%5Cu201cneuroblast%5Cu201d%20cluster%2C%20a%20highly%20cycling%20cluster%20that%20shares%20markers%20with%20sympathoblasts.%20The%20signature%20of%20the%20medullary%20SCP%20cluster%20differentiates%20neuroblastoma%20patients%20based%20on%20disease%20phenotype%3A%20The%20SCP%20signature%20score%20anticorrelates%20with%20ALK%20and%20MYCN%20expression%2C%20two%20indicators%20of%20poor%20prognosis.%20Furthermore%2C%20a%20high%20SCP%20signature%20score%20is%20associated%20with%20better%20overall%20survival%20rates.%20This%20study%20provides%20an%20insight%20into%20the%20developing%20adrenal%20gland%20and%20introduces%20the%20SCP%20gene%20signature%20as%20being%20of%20interest%20for%20further%20research%20in%20understanding%20neuroblastoma%20phenotype.%5CnAuthor%20Information%5CnEvelyn%20S.%20Hanemaaijera%2C1%2C%20Thanasis%20Margaritisb%2C1%2C%20Karin%20Sandersa%2Cc%2C%20Frank%20L.%20Bosa%2C%20Tito%20Candellib%2C%20Hanin%20Al-Saatia%2C%20Max%20M.%20van%20Noeselb%2C%20Friederike%20A.%20G.%20Meyer-Wentrupb%2C%20Marc%20van%20de%20Weteringa%2C%20Frank%20C.%20P.%20Holstegeb%2C%20and%20Hans%20Cleversa%2Cd%2C2aOncode%20Institute%2C%20Princess%20M%5Cu00e1xima%20Center%20for%20Pediatric%20Oncology%2C%203584%20CS%20Utrecht%2C%20The%20Netherlands%3BbPrincess%20M%5Cu00e1xima%20Center%20for%20Pediatric%20Oncology%2C%203584%20CS%20Utrecht%2C%20The%20Netherlands%3BcDepartment%20of%20Clinical%20Sciences%2C%20Faculty%20of%20Veterinary%20Medicine%2C%20Utrecht%20University%2C%203584%20CM%20Utrecht%2C%20The%20Netherlands%3BdOncode%20Institute%2C%20Hubrecht%20Institute%2C%20Royal%20Netherlands%20Academy%20of%20Arts%20and%20Sciences%20and%20University%20Medical%20Center%2C%203584%20CT%20Utrecht%2C%20The%20NetherlandsContributed%20by%20Hans%20Clevers%2C%20December%2015%2C%202020%20%28sent%20for%20review%20October%2026%2C%202020%3B%20reviewed%20by%20Olivier%20Delattre%20and%20Frank%20Speleman%29%5CnFootnotes%5Cu21b51E.S.H.%20and%20T.M.%20contributed%20equally%20to%20this%20work.%5Cu21b52To%20whom%20correspondence%20may%20be%20addressed.%20Email%3A%20h.clevers%40hubrecht.eu.Author%20contributions%3A%20E.S.H.%2C%20T.M.%2C%20M.v.d.W.%2C%20and%20H.C.%20designed%20research%3B%20E.S.H.%2C%20T.M.%2C%20H.A.-S.%2C%20and%20M.v.d.W.%20performed%20research%3B%20F.L.B.%20contributed%20new%20reagents%5C%2Fanalytic%20tools%3B%20E.S.H.%2C%20T.M.%2C%20K.S.%2C%20T.C.%2C%20M.M.v.N.%2C%20F.A.G.M.-W.%2C%20M.v.d.W.%2C%20F.C.P.H.%2C%20and%20H.C.%20analyzed%20data%3B%20E.S.H.%2C%20T.M.%2C%20M.v.d.W.%2C%20and%20H.C.%20wrote%20the%20paper%3B%20K.S.%2C%20M.M.v.N.%2C%20and%20F.A.G.M.-W.%20advised%20on%20survival%20analysis%3B%20and%20F.C.P.H.%20supervised%20single-cell%20analysis.Reviewers%3A%20O.D.%2C%20Institut%20Curie%3B%20and%20F.S.%2C%20Institute%20of%20Human%20Genetics.The%20authors%20declare%20no%20competing%20interest.This%20article%20contains%20supporting%20information%20online%20at%20https%3A%5C%2F%5C%2Fwww.pnas.org%5C%2Flookup%5C%2Fsuppl%5C%2Fdoi%3A10.1073%5C%2Fpnas.2022350118%5C%2F-%5C%2FDCSupplemental.%22%2C%22date%22%3A%222021%5C%2F02%5C%2F02%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1073%5C%2Fpnas.2022350118%22%2C%22ISSN%22%3A%220027-8424%2C%201091-6490%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.pnas.org%5C%2Fcontent%5C%2F118%5C%2F5%5C%2Fe2022350118%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-01T22%3A48%3A58Z%22%7D%7D%5D%7D
Hanemaaijer, E. S., Margaritis, T., Sanders, K., Bos, F. L., Candelli, T., Al-Saati, H., Noesel, M. M. van, Meyer-Wentrup, F. A. G., Wetering, M. van de, Holstege, F. C. P., & Clevers, H. (2021). Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype. Proceedings of the National Academy of Sciences, 118(5). https://doi.org/10.1073/pnas.2022350118 Cite
Full Article
Exit mobile version