The authors found that chemotherapy exacerbated the migration and CSC-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition markers Vimentin and Snail.
[European Journal of Pharmacology]
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Zhao, Y., Yang, X., Zhao, J., Gao, M., Zhang, M., Shi, T., Zhang, F., Zheng, X., Pan, Y., Shao, D., Li, J., He, K., & Chen, L. (2021). Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1. European Journal of Pharmacology, 895, 173887. https://doi.org/10.1016/j.ejphar.2021.173887 Cite
